instaGRAAL: chromosome-level quality scaffolding of genomes using a proximity ligation-based scaffolder

instaGRAAL: chromosome-level quality scaffolding of genomes using a proximity ligation-based scaffolder

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Abstract Hi-C exploits contact frequencies between pairs of loci to bridge and order contigs during genome assembly, resulting in roneverhart.com chromosome-level assemblies.Because few robust programs are available for this type of data, we developed instaGRAAL, a complete overhaul of the GRAAL program, which has adapted the latter to allow efficient assembly of large genomes.instaGRAAL features a number of improvements over GRAAL, including a modular correction approach that optionally integrates independent data.We validate the program using data for two brown algae, and human, to generate near-complete assemblies with minimal chicago cubs earrings human intervention.